The EFFORT Protein and PRECISe trials on protein dosing for critically ill patients
Rethinking Protein Dosing in the ICU
In this insightful webinar, leading experts examine recent clinical trial evidence on protein dosing in critically ill patients, challenging the long-standing belief that higher protein intake universally improves outcomes. Drawing on findings from the EFFORT and PRECISE trials, the discussion highlights that very high protein doses do not improve mortality, physical function or quality of life, and may even be harmful in certain patient groups. The session underscores the importance of moving beyond observational data and expert opinion toward high-quality randomized evidence, while shifting the focus of ICU nutrition from survival alone to long-term functional recovery and patient-centered outcomes.
Insights and Practical Takeaways for Healthcare Professionals
You will gain valuable knowledge about:
- Why high protein dosing (around 2 g/kg/day) does not improve clinical outcomes or quality of life and may negatively impact certain high-risk patients
- Evidence from randomized trials supporting moderate protein targets (around 1.2–1.5 g/kg/day) as a more appropriate range for most critically ill patients
- The importance of focusing on functional recovery and quality of life rather than mortality as primary endpoints in ICU nutrition research
- How timing and phases of critical illness influence protein needs, including the value of gradual progression rather than early high intake
- The limitations of a one-size-fits-all approach and the need to individualize protein dosing based on patient characteristics and condition
- Which patient subgroups (e.g., those on renal replacement therapy, severe trauma or burns) may require higher protein intake
- The feasibility of achieving targeted protein intake using structured, isocaloric enteral nutrition strategies in ICU settings
Watch and Expand Your Understanding
Watch the full video on Danone Nutricia Campus (DNC) to translate the latest randomized evidence on protein dosing into practical ICU nutrition strategies. Learn how to apply moderate, individualized protein targets and align nutrition practices with patient-centered outcomes such as functional recovery and quality of life. Explore related educational materials on Danone Nutricia Campus to access more expert insights and scientific resources in critical care nutrition.
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The EFFORT Protein and PRECISe trials on protein dosing for critically ill patients
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