This webinar explores the growing clinical challenge of Cow's Milk Allergy (CMA) in children and the role of pre-, pro- and synbiotics in managing allergic diseases. It discusses the potential mechanisms of actions for pre-, pro- and synbiotics, and their impact on the immune system and the gut microbiota. Additionally, it underscores the importance of evaluating each formula and biotic separately for effective treatment. The webinar also addresses the growing importance of real-world data and shares recent real world evidence on the impact of hypoallergenic formulas with synbiotics on the dietary management of cow’s milk allergy.