Synbiotics and the early-life microbiome: Evidence from c-section delivery to cow’s milk allergy

Understanding Synbiotics and the Early-Life Microbiome 

In this first DNC Science in Session: Biotics Special presented at LASPGHAN 2025, Prof. Yvan Vandenplas, Chairman of DNC Founder and consultant at the University Hospital of Brussels (UZ Brussels), discusses the link between C-section delivery, gut microbiota development, and cow’s milk allergy. Through a scientific lens, he explains how early microbial colonization influences the development of the immune system and the onset of immune-mediated and allergic conditions. The session sheds light on how birth mode and infant feeding shape the early-life gut microbiome, impacting long-term health outcomes. 

What You Will Learn as a Healthcare Professional 

This session provides evidence-based insights to support clinical practice. You will learn about: 

• The lasting impact of cesarean delivery on the gut microbiota and immune maturation. 

• The role of bifidobacteria in supporting immune and cognitive development in infancy. 

• How symbiotics, combining prebiotics and probiotics, help re-establish a balanced gut microbiota in C-section born or formula-fed infants, reducing risks of atopic dermatitis, infections, and immune imbalance.
• Prof. Vandenplas also explains the contribution of human milk oligosaccharides (HMOs), FOS/GOS, and Bifidobacterium breve M-16V in supporting a microbiota composition closer to that of breastfed infants.

Watch the Session and Explore Further 

Watch this insightful presentation on Danone Nutricia Campus to strengthen your understanding of early-life nutrition and microbiota management. Discover practical applications for supporting infant gut health and allergy prevention.  Check out our evidence-based resources to learn more about C-section and paediatric allergy, on our dedicated pages at DNC: C-Section & Paediatric Allergy