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Alzheimer's Disease Composite Score: a Post-Hoc Analysis Using Data from the LipiDiDiet Trial in Prodromal Alzheimer's Disease

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Expert Insights into Clinical Nutrition in Neurology

This peer-reviewed analysis highlights the use of the Alzheimer’s Disease Composite Score (ADCOMS) as a sensitive tool to detect intervention effects in prodromal Alzheimer’s disease. Drawing on data from the LipiDiDiet trial, the study evaluates how the multinutrient formulation Fortasyn Connect influences cognitive and functional decline over 24 months. By applying ADCOMS in a post-hoc analysis, researchers demonstrated that the intervention group experienced significantly less decline than the control group, particularly in domains related to memory and daily functioning. These findings reinforce the role of clinical nutrition and composite scoring systems in the early management of Alzheimer’s disease.

Practical Benefits for Healthcare Professionals

This resource equips you with new clinical insights to:

  • Explore how ADCOMS captures changes in cognitive and functional decline in early Alzheimer’s

  • Understand the added sensitivity of ADCOMS compared to traditional scales such as NTB and ADAS-cog

  • Review data showing a 36% reduction in decline with active nutritional intervention

  • Gain perspective on the CDR-SB and MMSE subdomain contributions to treatment responsiveness

  • Strengthen your approach to early intervention and long-term monitoring in prodromal AD populations

Access the Full Publication Now

Stay informed and elevate your clinical approach by engaging with this expert-led post-hoc analysis. Click “View Content” to download the full document from a trusted, peer-reviewed source.
More outcome data, methodology details, and subgroup findings are included in the complete article.

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lipididiet-composite-score

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