Sarcopenia, malnutrition and frailty are highly prevalent and interrelated in older hospitalized adults. During hospital admissions these conditions are often not addressed and tend to get worse during the trajectory of admission and after discharge, which can lead to a deterioration of physical function and a higher level of dependence and mortality. Sedentary behavior is common in older hospitalized adults due to the diseases leading to hospitalization, but also due to a lack of physical activity promotion and the hospital environment. The Pajama Paralysis movement stimulates physical activity and activities of daily living (such as dining together to stimulate oral intake), but implementation tends to be challenging. Evidence of focused interventions, e.g. nutritional supplementation to counteract sarcopenia, is promising, but still limited. A multidisciplinary, translational approach is warranted to enable hospitalized patients to recover from acute disease.